58) T. Nagasawa, M. Horitani, S. Kawaguchi, S. Higashiyama, Y. Hama, S. Mitsutake
The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids.
FEBS Open Bio (2021) 11,3081-3089

57) Y. Hama, E. Yamagata, N. Takahama, Y. Yoshimura, R. Yanagita, S. Mitsutake
Liberation of eicosapentaenoic acid and degradation of the major cell wall polysaccharide porphyran by fermentation of nori, the dried thalli of Pyropia yezoensis, with koji
Journal of Applied Phycology (2021) in press

56) T. Nagasawa, K. Ishimaru, S. Higashiyama, Y. Hama, S. Mitsutake
Teadenol A in microbial fermented tea acts as a novel ligand on GPR120 to increase GLP-1 secretion.
Food & Function (2020) 11,10534-10541

55) F.-T. Zohra, Y. Tominaga, Y. Matsumoto, N. Taniguchi, A. Okubo, S. Mitsutake, N. Kotoda
Relationship Between the Limonoid Content in Different Parts of the Sour Orange (Citrus aurantium L.) and the Ligand Activity of a Bile Acid Receptor, TGR5
The Horticulture Journal (2020) 89,384-393

54) H. Hamajima, M. Tanaka, M. Miyagawa, M. Sakamoto, T. Nakamura, T. Yanagita, S. Mitsutake, J. Wakayama, K. Nagao, H. Kitagaki
Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice.
Bioscience, Biotechnology, and Biochemistry (2019) 83, 1514-1522

53) S. Usuki, N. Tamura, T. Tamura, S. Higashiyama, K. Tanji, S. Mitsutake, A. Inoue, J. Aoki, K. Mukai, Y. Igarashi
Kondjac ceramide (kier) regulates keratinocyte migration by sema3A-like repulsion mechanism
Biochemistry and Biophysics Reports (2019) 17, 132-138

52) H. Hamamatsu, S. Mitsutake, S. Sakai, T. Okazaki, K. Watanabe, Y. Igarashi, K. Yuyama
Multiple roles of SMS2 in white and brown adipose tissues form diet-induced obese mice
J. Metabolic Syndrome (2018) 7, 241

51) M.M.M. Swamy, Y Murai, Y Ohno, K Jojima, A Kihara, S Mitsutake, Y Igarashi, J Yu, M Yao, Y Suga, M Anetai and K Monde
Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor
Chem. Commun. (2018) 54, 12758-12761

50) S. Esaki, T. Nagasawa, H. Tanaka, A. Tomonaga, D. Mikami, S. Usuki, H. Hamajima, S. Sakai, Y. Hama, Y. Igarashi, H. Kitagaki, S. Mitsutake*
The fungal 9-methylsphingadiene is a novel ligand for both PPARg and GPR120
J. Food Biochem. (2018) e12624

49) T Nagasawa, H Nakamichi, Y Hama, S Higashiyama, I Yasuyuki, S. Mitsutake*
Phytosphingosine is a novel activator of GPR120
J. Biochemistry
(2018) 164(1): 27-32

48) K Zama, S Mitsutake*, T Okazaki, Y Igarashi
Sphingomyelin in micro domains of the plasma membrane regulates amino acid-stimulated mTOR signal activation
Cell Biol Inter (2018) 42(7): 823-831
* corresponding author

47) S Saito, Y Murai, S Usuki, M Yoshida, M Hammam, S Mitsutake, K Yuyama, Y Igarashi, K Monde
Synthesis of nontoxic fluorous sphingolipids as molecular probes of exogenous metabolic studies for rapid enrichment by FSPE
Eur J Org Chem
(2017) 2017, 1045-1051

46) M Taniguchi, T Tasaki, H Ninomiya, Y Ueda, K Kuremoto, S Mitsutake, Y Igarashi, T Okazaki, T Takegami
Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus
Scientific Reports (2016) 6, 37829

45) Sakamoto H, Yoshida T, Sanaki T, Shigaki S, Morita H, Oyama M, Mitsui M, Tanaka Y, Nakano T, Mitsutake S, Igarashi Y, Takemoto H.
Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response.
Biochem Biophys Res Commun. (2017)
482(2): 202-207

44) Hamajima H, Matsunaga H, Fujikawa A, Sato T, Mitsutake S, Yanagita T, Nagao K, Nakayama J, Kitagaki H.
Japanese traditional dietary fungus koji Aspergillus oryzae functions as a prebiotic for Blautia coccoides through glycosylceramide: Japanese dietary fungus koji is a new prebiotic.
Springerplus. (2016), 5, 1321.

43) H Hamajima, A Fujikawa, M Yamashiro, T Ogami, S Kitamura, M Tsubata, S Tan, H Matsunaga, K Sawada, S Kumagai, N Hayashi, K Nagao, T Yanagita, T Oka, S Mitsutake, H. Kitagaki
Chemical Analysis of the Sugar Moiety of Monohexosylceramide Contained in Koji, Japanese Traditional Rice Fermented with Aspergillus
Fermentation 2016, 2(1), 2;

42) Sawada K, Sato T, Hamajima H, Jayakody LN, Hirata M, Yamashiro M, Tajima M, Mitsutake S, Nagao K, Tsuge K, Abe F, Hanada K, Kitagaki H.
Glucosylceramide contained in Koji mold-cultured cereal confers membrane and flavor modification and stress tolerance to Saccharomyces cerevisiae during coculture fermentation
Appl. Environ. Microbiol. (2015) 81, 3688-3698

41) Y. Hayashi, Y. Nemoto-Sasaki, T. Tanigawa, S. Oka, K. Tsuchiya, S. Mitsutake, T. Sugiura, A. Yamashita*
Sphingomyelin synthase 2, but not sphingomyelin synthase 1, is involved in HIV-1 envelope-mediated membrane fusion
J. Biol. Chem. (2014) 289: 30842-30856

40) H. Hanamatsu, S. Ohnishi, S. Sakai, K. Yuyama, S. Mitsutake, H. Takeda, Y. Igarashi*
Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults.
Nutrition & Diabetes (2014), 4: e141

39) K. Yuyama, H. Sun, S. Sakai, S. Mitsutake, M. Okada, H. Tahara, J. Furukawa, N. Fujitani, Y. Shinohara, Y. Igarashi*
Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice.
J. Biol. Chem. (2014) 289: 24488-24498

38) I. Murakami, S. Mitsutake*, N. Kobayashi, J. Matsuda, A. Suzuki, T. Shigyo, Y. Igarashi
Oral administration of phytosphingosine improves high-fat diet-induced glucose intolerance
Biosci. Biotech. Biochem. (2013) 77: 194-197

37) M. Taniguchi, K. Kitatani, T. Kondo, M.H. Nishimura, S. Asano, A. Hayashi, S. Mitsutake, Y. Igarashi, H. Umehara, T. Hiroyuki, J. Kigawa, and T. Okazaki*, 2012年
Regulation of autophagy and its associated cell death by sphingolipid rheostat: reciprocal role of ceramide and sphingosine-1-phosphate in the mTOR pathway
J. Biol. Chem. (2012) 287: 39898-39910

36) K. Zama, S. Mitsutake*, K. Watanabe, T. Okazaki, and Y. Igarashi
A sensitive cell-based method to screen for selective inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate
Chemistry and Physics of Lipids (2012) 165: 760-768

35) S. Mitsutake*, T. Date, H. Yokota, M. Sugiura, T. Kohama, Y. Igarashi
Ceramide kinase deficiency improve diet-induced obesity and insulin resistance
FEBS Letters (2012) 586: 1300-1305

34) Y. Shirakura, K. Kikuchi, K. Matsumura, K. Mukai, S. Mitsutake, and Y. Igarashi*
4, 8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin
Lipids in Health and Disease (2012) 11: 108

33) K. Yuyama, H. Sun, S. Mitsutake, and Y. Igarashi*
Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia
J. Biol. Chem. (2012) 287: 10977-10989

32) S. Asano, K. Kitatani, M. Taniguchi, M. Hashimoto, K. Zama, S. Mitsutake, Y. Igarashi, M. Takeya, A. Hayashi, H. Umehara, and T. Okazaki*
Regulation of cell migration by sphingomyelin synthases: Sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway
Mol. Cell. Biol. (2012) 32: 3242-3252

31) S. Mitsutake*, K. Zama, H. Yokota, T. Yoshida, M. Tanaka, M. Mitsui, M. Ikawa, M. Okabe, Y. Tanaka, T. Yamashita, H. Takemoto, T. Okazaki, K. Watanabe, and Y. Igarashi
Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes
J. Biol. Chem. (2011) 286: 28544-28555

30) N. Fujitani, Y. Takegawa, K. Araki, J. Furukawa, S. Mitsutake, Y. Igarashi, M. Ito, and Y. Shinohara*
Qualitative and quantitative cellular glycomics of glycosphingolipids based on rhodococcal EGCase I and II -assisted glycan cleavage, glycoblotting-assisted sample preparation and MALDI-TOF /TOF MS analysis
J. Biol. Chem. (2011) 286: 41669-41679

29) I. Murakami, Y. Wakasa, S. Yamashita, T. Kurihara, K. Zama, N. Kobayashi, Y. Mizutani, S. Mitsutake, T. Shigyo, and Y. Igarashi*
Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces
pastorianus activate peroxisome proliferator-activated receptors
Lipids in Health and Disease (2011) 10: 150

28) Y. Ohno, S. Suto, M. Yamanaka, Y. Mizutani, S. Mitsutake, Y. Igarashi, T. Sassa, and A. Kihara*
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis
Proc. Nati. Acad. Scie. USA (2010) 107: 18439-18444

27) S. Mitsutake, C. Suzuki, M. Akiyama, K. Tsuji, T. Yanagi, H. Shimizu, and Y. Igarashi*
ABCA12 dysfunction causes a disorder in glucosylceramide accumulation during keratinocyte differentiation
J. Dermatol. Sci. (2010) 60: 128-129

26) S. Mitsutake, H. Kumada, M. Soga, Y. Hurue, F. Asanuma, M. Nagira, M. Deguchi, T. Date, U. Yokose, Y. Inagaki, M. Sugiura, T. Kohama, and Y. Igarashi*
Ceramide kinase is not essential but might act as an Ca2+-sensor for mast cell activation
Prostaglandins and Other Lipid Mediators (2010) 93: 109-112

25) K. Tsuji, S. Satoh, S. Mitsutake, I. Murakami, J. J. Park, Q. Li, Y. T. Chang, S. K. Chung, and Y. Igarashi*
Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors
Bioorganic and Medicinal Chemistry Letters (2009) 19: 1643-1646

24) T. Tomiyama*, S. Kaihou, M. Ishida, H. Nishikawa, N. Yamazaki, K. Tsui, S. Mitsutake, and Y. Igarashi
The water retention effects and action for atopic dermatitis-like symptoms of ethyl alcohol extracts ( from Tamogi-take mushroom) on animal model of atopic dermatitis.
JOURNAL- JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE (2008) 61: 21-26

23) K. Tsuji, S. Mitsutake, U. Yokose, M. Sugiura, T. Kohama, and Y. Igarashi*
Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes
FEBS Journal (2008) 275: 3815-3826

22) S. Mitsutake, U. Yokose, M. Kato, I. Matsuoka, J. M. Yoo, T. J. Kim, H. S. Yoo, K. Fujimoto, Y. Ando, M. Sugiura, T. Kohama, and Y. Igarashi*
The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells
Biochem. Biophys. Res. Commun. (2007) 363: 519-524

21) S. Mitsutake, and Y. Igarashi*
Transbilayer movement of ceramide in the plasma membrane of live cells
Biochem. Biophys. Res. Commun. (2007) 359: 622-627

20) H. Kumada, S. Mitsutake, Y. Inagaki, S. Mitsunaga, H. Tsuchikawa, S. Katsumura, and Y. Igarashi*
Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast-cell activation
Biosci. Biotech. Biochem. (2007) 71: 2581-2584

19) T. Date, S. Mitsutake, and Y. Igarashi*
Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60
In Vitro Cellular and Developmental Biology-Animal (2007) 43: 321-323

18) K. Tsuji, S. Mitsutake, J. Ishikawa, Y. Takagi, M. Akiyama, H. Shimizu, T. Tomiyama, and Y. Igarashi*
Dietary glucosylceramide improves skin barrier function in hairless mice
J. Dermatol. Sci. (2006) 44: 101-107

17) S. Takeda, S. Mitsutake, K. Tsuji, and Y. Igarashi*
Apoptosis occurs via the ceramide recycling pathway in human HaCaT keratinocytes
J. Biochem. (2006) 139: 255-262

16) T. J. Kim, S. Mitsutake, and Y. Igarashi*
The interaction between the pleckstrin homology domain of ceramide kinase and phosphatidylinositol 4,5-bisphosphate regulates the plasma membrane targeting and ceramide 1-phosphate levels
Biochem. Biophys. Res. Commun. (2006) 342: 611-617

15) Y. Inagaki, S. Mitsutake, and Y. Igarashi*, 2006年
Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein
Biochem. Biophys. Res. Commun. (2006) 343: 982-987

14) S. Mitsutake, and Y. Igarashi*,
Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium sensor
J. Biol. Chem. (2005) 280: 40436-40441

13) T. J. Kim, S. Mitsutake, M. Kato, and Y. Igarashi*
The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity
FEBS Letters (2005) 579: 4383-4388

12) J. W. Kim, Y. W. Kim, Y. Inagaki, Y. A. Hwang, S. Mitsutake, Y. W. Ryu, W. K. Lee, H. J. Ha, C. S. Park, and Y. Igarashi*
Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases
Bioorganic and Medicinal Chemistry (2005) 13: 3475-3485

11) J. W. Kim, Y. Inagaki, S. Mitsutake, N. Maezawa, S. Katsumura, Y. W. Ryu, C. S. Park, M. Taniguchi, and Y. Igarashi*
Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1
Biochim. Biophys. Act. - Molecular and Cell Biology of Lipids (2005) 1738: 82-90

10) S. Yokota, Y. Taniguchi, A. Kihara, S. Mitsutake, and Y. Igarashi*
Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition
FEBS Letters (2004) 578: 106-110

9) S. Mitsutake, T. J. Kim, Y. Inagaki, M. Kato, T. Yamashita, and Y. Igarashi*
Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells
J. Biol. Chem. (2004) 279: 17570-17577

8) Y. Inagaki, P. Y. Li, A. Wada, S. Mitsutake, and Y. Igarashi*
Identification of functional nuclear export sequences in human sphingosine kinase 1
Biochem. Biophys. Res. Commun. (2003) 311: 168-173

7) M. Furusato, N. Sueyoshi, S. Mitsutake, K. Sakaguchi, K. Kita, N. Okino, S. Ichinose, A. Omori, and M. Ito*
Molecular cloning and characterization of sphingolipid ceramide N-deacylase from a marine bacterium, Shewanella alga G8
J. Biol. Chem. (2002) 277: 17300-17307

6) E. Romiti, E. Meacci, G. Tanzi, L. Becciolini, S. Mitsutake, M. Farnararo, M. Ito, and P. Bruni*
Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells
FEBS Letters (2001) 506: 163-168

5) S. Mitsutake, M. Tani, N. Okino, K. Mori, S. Ichinose, A. Omori, H. Iida, T. Nakamura, and M. Ito*
Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney
J. Biol. Chem. (2001) 276: 26249-26259

4) M. Tani, N. Okino, S. Mitsutake, T. Tanigawa, H. Izu, and M. Ito*
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized
J. Biol. Chem. (2000) 275: 3462-3468

3) M. Tani, N. Okino, S. Mitsutake, and M. Ito*
Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide
J. Biochem. (1999) 125: 746-749

2) S. Mitsutake, K. Kita, T. Nakagawa, and M. Ito*
Enzymatic synthesis of 14C-glycosphingolipids by reverse hydrolysis reaction of sphingolipid ceramide N-deacylase: detection of endoglycoceramidase activity in a seaflower
J. Biochem. (1998) 123: 859-863

1) S. Mitsutake, K. Kita, N. Okino, and M. Ito*
[14C]ceramide synthesis by sphingolipid ceramide N-deacylase: new assay for ceramidase activity detection
Anal. Biochem. (1997) 247: 52-57

15) 光武進
細胞膜スフィンゴミエリンの代謝制御による新規細胞膜ダイナミズム
生化学(Journal of Japanese Biochemical Society) (2017) 89, 86-89

14) S. Mitsutake*, and Y. Igarashi
“Sphingolipids in lipid microdomains and obesity”
Vitamins & Hormones (2013) 91 "Obesity": 271-284
Elsevier, Edited by G. Litwack (図が表紙に採用されました)

13) 光武進*、村上逸雄、五十嵐靖之
「食品成分スフィンゴ脂質による皮膚機能改善効果」
アレルギーの臨床 (2013) 33: 165-169

12) 村上逸雄、光武進*、小林直之、執行達朗、五十嵐靖之
「ビール酵母に含まれるファイトセラミドの消化吸収と新たに見いだされた生理活性」
アレルギーの臨床 (2012) 32: 77-81

11) 光武進*、五十嵐靖之
「スフィンゴ脂質研究の医薬品開発への応用展開」
バイオサイエンスとインダストリー (2012) 70: 102-107

10) 光武 進*, 五十嵐靖之
「セラミド関連脂質とメタボリックシンドローム」
「セラミド-基礎と応用-」ここまできたセラミド研究最前線」: (2011) 186-191
食品化学新聞社発刊、セラミド研究会編

9) 沖野望, 谷元洋, 光武進, 吉村征活, 合田初美, 伊東信*
構造から読み解く中性セラミダーゼの触媒機構.
細胞 (2009)41: 182-185.

8) 水谷有紀子, 光武進, 五十嵐靖之*
セラミド合成酵素とセラミドリン酸化酵素.
細胞 (2009)41: 174-177.

7) Y. Mizutani, S. Mitsutake, K. Tsuji, A. Kihara, Y. Igarashi*, 2009年
Ceramide biosynthesis in keratinocyte and its role in skin function.
Biochimie (2009) 91: 784-790.

6) A. Kihara*, S. Mitsutake, Y. Mizutani, Y. Igarashi
Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.
Progress in Lipid Research (2007) 46: 126-144.

5) S. Mitsutake*, T. J. Kim, Y. Igarashi
Ceramide 1-phosphate
Sphingolipid Biology: (2006) 209-215, Springer (Tokyo),
Edited by Y. Hirabayashi, Y. Igarashi, A.H. Merrill

4) 光武進*、五十嵐靖之
セラミドキナーゼの機能と阻害剤の発見
バイオサイエンスとインダストリー　(2006) 64: 36-37

3) M. Ito*, N. Okino, M. Tani, S. Mitsutake, K. Kita
Molecular evolution of neutral ceramidase: from bacteria to mammals
Ceramide Signaling: (2003) 41-48, Landes Bioscience, Edited by A.H. Futerman

2) 伊東信*, 沖野望, 谷元洋, 光武進, 森薫
中性セラミダーゼの分子進化　- 病原因子とシグナリング分子 -
蛋白質核酸酵素 (2002) 47: 455-462.

1) M. Ito*, S. Mitsutake, M. Tani, K. Kita
Enzymatic synthesis of [14C]ceramide, [14C]glycosphingolipids, and omega-aminoceramide.
Methods in Enzymology (2000) 311 "Sphingolipid metabolism and cell signaling": 682-689
Elsevier, Edited by A.H. Merrill and Y.A. Hannun